Loss of bidirectional striatal synaptic plasticity in L-DOPA–induced dyskinesia
By B. Picconi, D. Centonze, Kerstin Håkansson, G. Bernardi, Paul Greengard, G. Fisone, M. Cenci, P. Calabresi. Nature Neuroscience, 2003
823 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/d9bfbfec7f7140a95bdd9a9b3af0d2966421f4cb
How researchers see this paper
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In Cellular and Molecular Neuroscience
- Michael A. Nitsche
- John C. Rothwell
- Walter Paulus
- N. Lang
- Hartwig Roman Siebner
- Michael J Frank
- Roger N. Lemon
- Terrence J. Sejnowski
In Neurology
- Michael A. Nitsche
- Walter Paulus
- John C. Rothwell
- N. Lang
- Hartwig Roman Siebner
- Roger N. Lemon
- Agnes Flöel
- Kailash Bhatia
Citations in the corpus
- Preconditioning of Low-Frequency Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation: Evidence for Homeostatic Plasticity in the Human Motor Cortex (2004, background): “…a illustrates the effects of anodal TDCS followed by 1 Hz rTMS. b presents the effects of cathodal TDCS followed by 1 Hz rTMS. Symbols and error bars represent the mean MEP amplitude and SEM, respectively. ated with abnormal homeostatic regulation of LTP in the striatum (Picconi et al., 2003).”
- Convergent evidence for abnormal striatal synaptic plasticity in dystonia (2009, positive): “One theory is that LIDs develop as an inability to depotentiate from LTP, because among 6- hydroxydopamine (6-OHDA) rats treated with L-DOPA, only those developing LIDs showed impaired synaptic depotentiation (Picconi et al., 2003).”
- Dynamic Dopamine Modulation in the Basal Ganglia: A Neurocomputational Account of Cognitive Deficits in Medicated and Nonmedicated Parkinsonism (2005, background): “In support of this theory, rats with L-Dopainduced dyskinesia had a selective impairment in the depotentiation (i.e., reversal of LTP) of corticostriatal synapses (Picconi et al., 2003), ostensibly due to changes in the D1 receptor pathway.”
- A common polymorphism in the brain‐derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS (2008, background): “Similarly, disorders of metaplasticity have been postulated to underlie susceptibility to L-DOPA-induced dyskinesia in Parkinson’s disease (Picconi et al. 2003; Linazasoro, 2005).”