Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: A Randomized Controlled Trial

By T. Farchione, C. Fairholme, K. Ellard, Christina L. Boisseau, Johanna Thompson-Hollands, Jenna R Carl, M. Gallagher, David H. Barlow. The Behavior Therapist, 2012

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This study further evaluates the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP). A diagnostically heterogeneous clinical sample of 37 patients with a principal anxiety disorder diagnosis was enrolled in a randomized controlled trial (RCT) involving up to 18 sessions of treatment and a 6-month follow-up period. Patients were randomly assigned to receive either immediate treatment with the UP (n=26) or delayed treatment, following a 16-week wait-list control period (WLC; n= 11). The UP resulted in significant improvement on measures of clinical severity, general symptoms of depression and anxiety, levels of negative and positive affect, and a measure of symptom interference in daily functioning across diagnoses. In comparison, participants in the WLC condition exhibited little to no change following the 16-week wait-list period. The effects of UP treatment were maintained over the 6-month follow-up period. Results from this RCT provide additional evidence for the efficacy of the UP in the treatment of anxiety and comorbid depressive disorders, and provide additional support for a transdiagnostic approach to the treatment of emotional disorders.

Subfields: Clinical Psychology, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/d979710dd36f9e3710e1f0b3ca37cc873dd26e6a

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In Clinical Psychology

In Experimental and Cognitive Psychology

Citations in the corpus

Odd Couple? Reenvisioning the Relation Between Science and Practice in the Dissemination-Implementation Era (2014, background): “MTFC has demonstrated benefit over usual group and residential care in RCTs with delinquent boys and girls, youths leaving a state hospital setting, and youths in state-supported foster care (D. K. Smith & Chamberlain, 2010).”
The Four-Function Model of Nonsuicidal Self-Injury (2014, background): “…across anxiety, depression, and related disorders by addressing key aspects of emotion processing and regulation and has shown efficacy in treating anxiety and co-occurring mood disorders in initial trials (Ellard, Fairholme, Boisseau, Farchione, & Barlow, 2010; Farchione et al., 2012).”
The Nature, Diagnosis, and Treatment of Neuroticism (2014, methodology): “…more directly have provided preliminary support for the notion that psychological interventions can address temperamental vulnerabilities and that such improvements are associated with a range of beneficial treatment outcomes (Carl et al., 2013; Farchione et al., 2012; Kennedy et al., 2009).”
Mental Health Smartphone Apps: Review and Evidence-Based Recommendations for Future Developments (2016, positive): “The UP has yielded very promising results across various emotional disorders, reducing psychopathology [85] and improving psychological well-being [86].”
The Hierarchical Taxonomy of Psychopathology (HiTOP): A Dimensional Alternative to Traditional Nosologies (2017, positive): “Transdiagnostic cognitive–behavioral therapy and even disorder-specific psychotherapies have been found to reduce symptoms of various internalizing conditions (Farchione et al., 2012; Newby et al., 2013; Rodriguez-Seijas, Eaton, & Krueger, 2015).”