Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.

By S. Sandur, M. Pandey, Bokyung Sung, K. Ahn, A. Murakami, Gautam Sethi, P. Limtrakul, V. Badmaev, Bharat B. Aggarwal. Carcinogenesis, 2007

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Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. (2008, background): “[30] Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, et al.”
Curcumin as "Curecumin": from kitchen to clinic. (2008, background): “Although most studies indicate that curcumin glucuronides and THC are less active than curcumin [154,166], others suggest otherwise [20,21,89,167–172].”
A Review of Curcumin and Its Derivatives as Anticancer Agents (2019, background): “O-methoxy substitution was found to be more effective in suppressing nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), but this modification has also affected the lipophilicity of curcumin [28].”
Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. (2014, background): “reported that the potency for the suppression of tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kB) activation ranked curcumin > desmethoxycurcumin > bisdesmethoxycurcumin suggesting a critical role of the methoxy groups on the phenyl rings [4].”
Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases (2008, background): “It has been reported that curcumin exhibit both antioxidant and prooxidant activities (Sandur et al., 2007a, Sandur et al., 2007b).”