Treatment of periodontitis and endothelial function.

By M. Tonetti, F. D’Aiuto, L. Nibali, A. Donald, Clare Storry, M. Parkar, J. Suvan, A. Hingorani, P. Vallance, J. Deanfield. New England Journal of Medicine, 2007

1,347 citations recorded by the source corpus.

Subfields: Oral Surgery, Periodontics, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/d9038b1c098fcdf470519412d45f317ce3b99fea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oral Surgery

1. S. Warnakulasuriya
2. I. Lamster
3. G. Hajishengallis

In Periodontics

1. G. Hajishengallis
2. J. Huizinga
3. S. Paraskevas
4. S. Warnakulasuriya
5. I. Lamster
6. R. Darveau
7. Panos N. Papapanou
8. E. Lalla

In Public Health, Environmental and Occupational Health

1. Panos N. Papapanou
2. E. Lalla

Citations in the corpus

• Global burden of oral diseases: emerging concepts, management and interplay with systemic health. (2016, background): “…periodontal care on reduction of systemic inflammation, and improvement of certain biomarkers of CVD and endothelial function, as well as a decrease in blood glucose level in subjects with type 2 DM (Tonetti et al, 2007; Lalla and Papapanou, 2011; Lockhart et al, 2012; Tonetti and Kornman, 2013).”
• A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. (2008, background): “In the Tonetti et al. (2007) study, the difference between the intensive periodontal treatment group and the control group receiving supragingival scaling/polishing was 1.4 mg/l at 2 and 6 months post-treatment, but failed to reach statistical significance.”
• Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues (2019, background): “Although intensive mechanical periodontal treatment of patients with severely damaged periodontal tissues can cause an acute systemic inflammatory response and impair endothelial function, this occurs only transiently and, after six months, a significantly improved endothelial function is reached [8”
• Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis (2010, positive): “The concept of endothelial inflammatory activation is further supported by a recent randomized controlled trial in which intensive treatment of periodontitis, a common potential source of low-grade inflammation, resulted in an improvement in brachial FMD [ 34 ].”
• European Guidelines on Cardiovascular Disease Prevention in Clinical Practice (Version 2012) (2012, neutral): “Periodontitis can be considered a risk indicator for a generally decreased cardiovascular health status and its treatment is indicated as well as management of the underlying cardiovascular risk factors.(190)”
• A Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and the Complement Pathway (2011, background): “Porphyromonas gingivalis, a low-abundance oral anaerobic bacterium, is implicated in periodontitis and associated systemic Cell Host & conditions (Desvarieux et al., 2005; Genco and Van Dyke, 2010; Lundberg et al., 2010; Pihlstrom et al., 2005; Tonetti et al., 2007).”