Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial.

By C. Grigor, H. Capell, A. Stirling, A. McMahon, Peter Lock, R. Vallance, W. Kincaid, D. Porter. The Lancet, 2004

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Defining minimal disease activity in psoriatic arthritis: a proposed objective target for treatment (2009, background): “4) resulted in significantly better clinical and radiographic outcomes compared with routine care with no formal therapeutic protocol.(3) Many recent RA studies such as BeSt(4) have used similar objective measures (usually the DAS) to guide treatment, and this is now being translated into routine cl”
Treating rheumatoid arthritis to target: recommendations of an international task force (2010, positive): “28 29 However, the Expert Committee felt that, while being an important step and a major alternative goal, reaching LDA could only pertain to patients with long-standing RA whose disease may have become refractory to therapeutic intervention.”
Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. (2005, positive): “use accordingly has resulted in improved outcomes (23).”
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs (2010, positive): “(11) Intensive medication strategies—This statement supplements several of the previous recommendations on drug treatment.”