SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice
By S. Schoch, F. Deák, A. Königstorfer, M. Mozhayeva, Y. Sara, T. Sūdhof, E. Kavalali. Science, 2001
665 citations recorded by the source corpus.
Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d84812a75fe04352831056126e547f17e8c78ec4
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Citations in the corpus
- Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map. (2004, background): “For example, the spontaneous firing role in synaptic vesicle release (Schoch et al., 2001; of sensory neurons may be required to allow a geneti- Sudhof, 1995).”
- Redundant functions of RIM1α and RIM2α in Ca2+‐triggered neurotransmitter release (2006, background): “The mutant mice did not respond to tactile stimuli, and exhibited an abnormal body posture similar to synaptobrevin 2 KO mice (Figure 3; Schoch et al, 2001), suggesting that they were paralyzed.”
- SNAREs and traffic. (2005, background): “VAMP2 [134] Die after birth; 100-fold d VAMP3 [137] No major defects VAMP8 [62] Defect in regulated exocy Syn4 [141] Die before E7.”
- Mechanisms of membrane fusion: disparate players and common principles (2008, background): “The residual release seen in synaptobrevin −/− and Snap25 −/− mice is likely to be attributable to compensation by other isoform”
- The synaptic vesicle cycle. (2004, neutral): “First, deletion of synaptobrevin caused a major impairment of synaptic vesicle exocytosis but left approximately 10% of exocytosis intact (Schoch et al. 2001).”
- PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005, background): “Genetic disruption of neuronal SNAREs in Drosophila, Caenorhabditis elegans, and mice shows that SNARE is essential for evoked synaptic transmission but is not always involved in spontaneous synaptic events (67, 133, 403, 484, 487, 572), indicating that the exocytotic processes of evoked and spontan”
- Secretory granule exocytosis. (2003, background): “Similarly, genetic ablation of synaptic SNAREs in Drosophila melanogaster, Caenorhabditis elegans, and Mus musculus abolishes evoked neurotransmission (533, 678, 681, 825).”
- Modification of intracellular membrane structures for virus replication (2008, background): “VAP is a multifunctional protein [65] [66] [67] [68] [69] [70] that is involved in intracellular transport, including the regulation of COPI-mediated transport 71, 72 .”