Spatial regulation of β-actin translation by Src-dependent phosphorylation of ZBP1

By S. Hüttelmaier, Daniel Zenklusen, M. Lederer, J. Dictenberg, M. Lorenz, Xiuhua Meng, G. Bassell, J. Condeelis, R. Singer. Nature, 2005

672 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d7b766cc558eb8a038b9ce86fffa1a7306b6e94d

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In Molecular Biology

Citations in the corpus

RNA‐binding proteins and post‐transcriptional gene regulation (2008, positive): “It is thought that phosphorylation of ZBP1 by the Src tyrosine kinase leads to decreased binding affinity to b-actin mRNA, and ultimately derepression of translation [85].”
Translational control of long-lasting synaptic plasticity and memory. (2009, positive): “Phosphorylation of ZBP1/IMP1 by Src reduces its RNA-binding affinity and relieves translational repression (Huttelmaier et al., 2005).”
ZBP2 Facilitates Binding of ZBP1 to β-Actin mRNA during Transcription (2007, background): “Recent studies revealed that similar to the case for primary neurons, -actin mRNA was localized to the cell periphery and neurites upon inducing differentiation (28).”
Single-Cell and Single-Molecule Analysis of Gene Expression Regulation (2016, background): “Therefore, association of β-actin transcripts with ZBP1 and ribosomes is anticorrelated, and these results corroborate prior observations that sequestration by ZBP1 leads to translational repression at the nuclear periphery (70).”
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? (2012, positive): “Spatially restricted translation of localized ACTB mRNAs is presumably activated by Src-mediated phosphorylation of IGF2BP1 [6].”
RNA-Binding Proteins in Cancer: Old Players and New Actors. (2017, background): “IMP1 associates with the b-actin transcript in the nucleus, priming the mRNA for translational silencing in the cytoplasm, but without affecting its stability [104].”
BDNF-induced local protein synthesis and synaptic plasticity. (2014, positive): “This is abrogated through Src-dependent phosphorylation of ZBP1, which results in the release of b-actin mRNA from ZBP1-containing granules and local translation of b-actin (Huttelmaier et al., 2005).”
mRNA Localization: Gene Expression in the Spatial Dimension (2009, positive): “Of note, ZBP1 has been shown to be phosphorylated by Src kinase, resulting in reduced binding of ZBP1 to RNA and to increased translation of b-actin in neuroblastoma cells (Huttelmaier et al., 2005).”
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets (2009, neutral): “ZBP1 blocks 60S joining to the 43S PIC (Huttelmaier et al., 2005).”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “For instance, ZBP1 induces translational silencing as well as incorporation of mRNA into RNPs (Huttelmaier et al., 2005; Tiruchinapalli et al., 2003; Zhang et al., 2001).”