Adaptive gain and the role of the locus coeruleus–norepinephrine system in optimal performance

By Gary S. Aston-Jones, J. Cohen. The Journal of comparative neurology, 2005

629 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d7b3aa30245cbd2922a8955e77ade2cf8fe8580b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

Citations in the corpus

Rare Neural Correlations Implement Robotic Conditioning with Delayed Rewards and Disturbances (2013, background): “Neuromodulation, however, involves a variety of modulatory chemicals, which are observed to regulate a spectrum of neural functions, from arousal to attention, exploration, exploitation, memory consolidation, and other (Hasselmo, 1995; Marder and Thirumalai, 2002; Aston-Jones and Cohen, 2005).”
The Neuromodulatory System: A Framework for Survival and Adaptive Behavior in a Challenging World (2008, background): “In particular, the orbitofrontal cortex, which is related to the evaluation of reward, and the anterior cingulate cortex, which is related to the evaluation of cost, project to the locus coeruleus and drive phasic responses (Aston-Jones & Cohen, 2005).”
as a Robot Controller Neuromodulation as a Robot Controller A Brain-Inspired Strategy for Controlling Autonomous Robots (2009, background): “…systems is to drive an organism to be decisive when environmental conditions call for such actions and allow the organism to be more exploratory when there are no pressing events [1], [5] 2) the main difference between neuromodulatory systems is the environmental stimuli that activate them.”
From modulated Hebbian plasticity to simple behavior learning through noise and weight saturation (2012, background): “A low modulatory value, or tonic value, implies small changes and is useful in conditions of low relevance for learning, as opposed to phasic values (Aston-Jones and Cohen, 2005; Krichmar, 2008).”
Beyond eye gaze: What else can eyetracking reveal about cognition and cognitive development? (2016, methodology): “According to this theory, intermediate levels of tonic LC activity, leading to focused attention and task engagement, are linked to exploitation, whereas high levels of tonic LC activity, resulting in distractibility and task disengagement, are linked to exploration (Aston-Jones and Cohen, 2005).”