Gene Therapy Using Adeno-Associated Virus Vectors

By Shyam Daya, K. Berns. Clinical Microbiology Reviews, 2008

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State-of-the-art gene-based therapies: the road ahead (2011, background): “The therapeutic expression cassette replaces rep and cap , leaving the viral inverted terminal repeats as the only viral sequence”
Delivering CRISPR: a review of the challenges and approaches (2018, background): “The virus itself is able to efficiently infect cells while provoking little to no innate or adaptive immune response or associated toxicity, at least upon first treatment with a serotype (Daya and Berns, 2008).”
Therapeutic Strategies for Enhancing Angiogenesis in Wound Healing (2018, methodology): “These viruses are characterized by low immunogenicity and the need for a helper virus to replicate [217].”