Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index.
By Lisa Martin, Laura Birdsell, N. Macdonald, T. Reiman, M. Clandinin, L. Mccargar, R. Murphy, Sunita Ghosh, M. Sawyer, Vickie E. Baracos. Journal of Clinical Oncology, 2013
2,381 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology, Physiology
View Paper: https://www.semanticscholar.org/paper/d79c5df2627384f3aa011b756c001cb27a275e6a
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Citations in the corpus
- Prognostic value of sarcopenia in adults with solid tumours: A meta-analysis and systematic review. (2016, methodology): “that also utilised optimal stratification to define thresholds associated with increased mortality and included 1,473 patients (the largest analysis to date) with lung or GI malignancies and incorporated both sex-specific and body mass index (BMI) cut-offs (43 cm/m for men BMI <25, 53 cm/m for men B”
- EASL Clinical Practice Guidelines on nutrition in chronic liver disease (2018, positive): “Normal CT measures and cut-off values to define sarcopenia were initially derived from an oncologic population.(26) Cut-off values derived from cirrhotic patients on the liver transplant list and based on clinical outcomes have only recently been suggested (50 cm(2)/m(2) for men and 39 cm(2)/m(2) fo”
- ESPEN guidelines on nutrition in cancer patients. (2017, background): “Studies of the body composition of patients with cancer reveal that it is specifically the loss of skeletal muscledwith or without loss of fatdwhich is the main aspect of cancer-associated malnutrition that predicts risk of physical impairment, post-operative complications, chemotherapy toxicity, an”
- Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma. (2015, background): “Furthermore, loss of skeletal muscle, called sarcopenia, is associated with poor prognoses of several cancers including HCC [10,11].”
- Measurement of skeletal muscle radiation attenuation and basis of its biological variation (2014, background): “Martin et al. (2013) reported that reduced muscle attenuation was independently prognostic of poor survival in a large cohort of patients with solid tumours of the lung and gastrointestinal tract.”
- Diagnostic criteria for the classification of cancer-associated weight loss. (2015, methodology): “Separate work clearly demonstrates that skeletal muscle loss is particularly detrimental in obese and overweight patients with cancer.(15,35) In obese patients with advanced solid tumors, sarcopenia (severe muscle depletion)(14) and sarcopenia plus concurrent WL(34) were associated with poor prognos”