Segregating Sister Genomes: The Molecular Biology of Chromosome Separation

By Kim Nasmyth. Science, 2002

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Dynamics of cancer progression (2004, background): “A large number of genes that trigger CIN when mutated have been discovered in Saccharomyces cerevisiae”
Controlling the double helix (2003, background): “After DNA replication, the sister chromatids are held together initially by a multisubunit complex called cohesin, while a second complex, condensin, helps to compact the chromosome”
The Mad2 spindle checkpoint protein has two distinct natively folded states (2004, background): “Active separase then cleaves the Scc1 subunit of cohesin, allowing the spindle microtubules to pull the separated chromatids to opposite poles of the cell (for a review, see ref”
Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes (2006, unknown): “The now burgeoning fi eld of oxidants in biological systems rose from obscurity with the cardinal discovery that the common red cell enzyme erythrocuprein was both ubiquitous and protective , functioning as a superoxide dismutase (SOD; McCord and Fridovich, 1969).”
Protein Metamorphosis: The Two-State Behavior of Mad2 (2008, background): “Degradation of securin and cyclin B activates separase, which cleaves the cohesin complex that maintains sisterchromatid cohesion (Nasmyth, 2002; Onn et al., 2008).”