Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis.
By P. Puig, P. Legoix, O. Bluteau, J. Belghiti, D. Franco, Frederic Binot, G. Monges, G. Thomas, P. Bioulac-Sage, J. Zucman‐Rossi. Gastroenterology, 2001
598 citations recorded by the source corpus.
Subfields: Hepatology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d76a58982e946a1f7b6820fd02e7c2b11bda0574
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In Hepatology
- J. Llovet
- Jordi Bruix1 , 2
- V. Mazzaferro
- Yujin Hoshida
- S. Friedman
- A. Villanueva
- Riccardo Lencioni
- M. Sherman
In Molecular Biology
Citations in the corpus
- Focal Gains of Vascular Endothelial Growth Factor A and Molecular Classification of Hepatocellular Carcinoma (2008, background): “Mutation status (CTNNB1 exon 3 or TP53 exons 5–8) and immunohistochemical staining are indicated in grayscale: present (black ), absent (gray ), or missing (white ) data.”
- iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “Such changes occur more frequently in HBV-related HCC than in HCC attributable to other causes (Laurent-Puig et al., 2001).”
- Targeting cancer stem cell pathways for cancer therapy (2020, background): “Some Wnt activation is caused by mutations in Wnt components, such as Axin mutation in gastrointestinal cancers,(136) APC mutation in colorectal cancer,(137) and β-catenin mutation in gastric cancer and liver cancer.(138,139) GSK3 genes are critical for β-catenin regulation; therefore, many research”
- Wnt/beta-catenin pathway: modulating anticancer immune response (2017, background): “β-catenin mutations have been implicated in early steps of carcinogenesis by activating the WNT pathway in gastric and non-hepatitis-related hepatocellular cancers [29, 30].”