Divide and conquer: A defense of functional localizers

By Rebecca Saxe, Matthew Brett, Nancy Kanwisher. NeuroImage, 2006

572 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d755e8055157d6431ee19c33f457a53a9ba59c0d

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In Cognitive Neuroscience

Citations in the corpus

Which fMRI clustering gives good brain parcellations? (2014, background): “The choice of the region(s) can be based on prior experiments (e.g. Saxe et al. (2006)).”
The preregistration revolution (2018, background): “Correcting the diagnosticity of P values for the number of tests that were actually conducted is relatively straightforward (33, 34), although inconsistently––even rarely––applied in practice (35, 36).”
Cross‐validation failure: Small sample sizes lead to large error bars (2017, background): “For instance, to study cognition, standard localizertype paradigms (Saxe et al., 2006) can easily be shared across many acquisitions, leading to large databases (Pinel et al.”
Building a Science of Individual Differences from fMRI. (2016, methodology): “Functional localizers have traditionally been used to improve validity [36]: in an independent functional MRI run, a task designed to activate a ROI is performed, and the ROI is defined in each individual from a statistical parametric map as one of the clusters that exceeds a given threshold.”
An algorithmic method for functionally defining regions of interest in the ventral visual pathway (2012, background): “The LOC responded signi ﬁ cantly more strongly to both objects and bodies than any other category (Main Effect contrasts, all p's b 0.001),consistent with previous reports (Saxe et al., 2006b).”
Probabilistic Maps of Visual Topography in Human Cortex. (2015, background): “This “region-of-interest” (ROI) approach is a powerful way to combine data across subjects (Saxe et al. 2006), under the assumption that each ROI represents a meaningful and consistent division of cortex.”
Innocent intentions: a correlation between forgiveness for accidental harm and neural activity. (2009, background): “…response in the RTPJ is high when subjects read stories about a character's thoughts, beliefs, knowledge but low during stories containing other socially relevant information, for example, a character's physical or cultural traits, or even internal sensations such as hunger (Saxe & Powell, 2006).”
Activity flow over resting-state networks shapes cognitive task activations (2016, background): “Notably, this bifurcation mirrors the classic ‘localized’ versus ‘distributed’ neural processing debate 4–7 , such that the relationship between localized cognitive task activations and distributed FC is also relevant to this broader theoretical divide in neuroscience.”
Differential selectivity for dynamic versus static information in face-selective cortical regions (2011, unknown): “However, no prior study has directly compared the response to dynamic versus static stimuli in these and other face-selective regions using data independent of that used to define the regions of interest (Saxe et al., 2006; Vul and Kanwisher, 2011).”
Contributions of episodic retrieval and mentalizing to autobiographical thought: evidence from functional neuroimaging, resting-state connectivity, and fMRI meta-analyses (2014, methodology): “We expect that more fine-grained comparisons of episodic retrieval, mentalizing, and autobiographical tasks – using either meta-analytic approaches or individual subject-defined ROIs (e.g. Saxe et al., 2006; Nieto-Castañón and Fedorenko, 2013) – should produce even clearer insights into the pattern ”
Imaging the deep cerebellar nuclei: A probabilistic atlas and normalization procedure (2011, unknown): “The method combines the spatial specificity of ROI analyses and the information richness of map-wise approaches (for a debate between these two approaches see: Friston et al., 2006; Saxe et al., 2006).”
Visual Topography of Human Intraparietal Sulcus (2007, background): “These retinotopically defined borders provide important and practical “func- tional landmarks” (Saxe et al., 2006) for the interpretation of task-related activations within individual subjects.”
Pupil diameter covaries with BOLD activity in human locus coeruleus (2014, methodology): “Hence, we leveraged our earlier analysis of brain regions that relate to fluctuations in pupil diameter to derive a “functional localizer” for the LC that had greater spatial and functional specificity than the LC atlas considered as a whole [Saxe et al., 2006].”
Puzzlingly High Correlations in fMRI Studies of Emotion, Personality, and Social Cognition 1 (2009, background): “In another Science article, Singer et al. (2004) found that the magnitude of differential activation within the ACC and left insula induced by an empathy-related manipulation displayed a correlation between .”