Vitamin D: its role and uses in immunology 1

By H. DeLuca, M. Cantorna. The FASEB Journal, 2001

881 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Pathology and Forensic Medicine, Physiology

View Paper: https://www.semanticscholar.org/paper/d73f60a5a09f305c0dd43cd1e9a81f0e7954a3da

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In Nutrition and Dietetics

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Citations in the corpus

The vitamin D epidemic and its health consequences. (2005, background): “1,25(OH)2D helps regulate cell growth and maturation, stimulates insulin secretion, inhibits renin production, and modulates the functions of activated T and B lymphocytes and macrophages (10,11,16,17).”
Circulating 25-Hydroxy-Vitamin D and Risk of Cardiovascular Disease: A Meta-Analysis of Prospective Studies (2012, background): “Vitamin D has pleiotropic effects that may favorably influence cardiovascular health through multiple mechanisms, including downregulation of the renin–angiotensin system,(3) enhancement in insulin secretion and insulin sensitivity,(4,5) protection against angiogenesis,(6) and modulation of inflamma”
Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. (2004, background): “Thus, it is not at all surprising that 1,25(OH)2D has a multitude of biologic effects that are noncalcemic in nature (9, 31, 45 ).”
Nonclassic actions of vitamin D. (2009, background): “In a number of experimental models (65, 66) including inflammatory arthritis, autoimmune diabetes, experimental allergic encephalitis (a model for multiple sclerosis), and inflammatory bowel disease, 1,25(OH)2D3 administration has prevented and/or treated the disease process.”
Noncalcemic actions of vitamin D receptor ligands. (2005, background): “(OH)2D3 has potent immunomodulatory effects on many immune cell types including both innate and adaptive immune cells (79-81).”
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. (2016, background): “The protective effect of 1,25(OH)2D3 in EAE is associated with inhibition of IL-12 and IL-17 and requires IL-10 signaling (217, 298, 421).”
Vitamin D in preventive medicine: are we ignoring the evidence? (2003, background): “Calcitriol is able to markedly suppress disease activity in an animal model of rheumatoid arthritis ( DeLuca & Cantorna , 2001 ) .”
Gender differences in autoimmune disease. (2014, neutral): “effects on T lymphocytes, B lymphocytes, and dendritic cells (Arnson et al., 2007; Deluca and Cantorna, 2001).”
Contribution of Selected Vitamins and Trace Elements to Immune Function (2007, background): “Further, there is evidence from human epidemiological studies that vitamin D status influenced the occurrence of Th1-mediated autoimmunity diseases which is in accordance with 1,25(OH) 2 D 3 to inhibit maturation of DCs and downregulate production of the immunostimulatory IL-12, and the observed in”