Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

By S. Mitragotri, Paul A Burke, R. Langer. Nature reviews. Drug discovery, 2014

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Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery. (2019, positive): “98 Other important features of mRNA-based therapeutics include low risk of insertional mutagenesis, transient production of encoded protein, and cytoplasmic activity of mRNA lowering the cellular barriers for functional delivery.”
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, neutral): “Here, we briefly discuss the potential immunogenicity of PEG and the development of PEG alternatives, which has been thoroughly discussed elsewhere [28, 81-84].”
Controlled Drug Delivery Systems: Current Status and Future Directions (2021, neutral): “This helps to bridge the gap between in vivo animal studies and the clinical study results [50].”
Exploiting sequence and stability information for directing nanobody stability engineering (2017, background): “Its relevance becomes more and more apparent for therapeutic strategies, during which antibodies are usually administered at high concentrations [15,16].”