Genomic basis for natural product biosynthetic diversity in the actinomycetes

By M. Nett, H. Ikeda, B. Moore. Natural product reports (Print), 2009

689 citations recorded by the source corpus.

The phylum Actinobacteria hosts diverse high G + C, Gram-positive bacteria that have evolved a complex chemical language of natural product chemistry to help navigate their fascinatingly varied lifestyles. To date, 71 Actinobacteria genomes have been completed and annotated, with the vast majority representing the Actinomycetales, which are the source of numerous antibiotics and other drugs from genera such as Streptomyces, Saccharopolyspora and Salinispora. These genomic analyses have illuminated the secondary metabolic proficiency of these microbes – underappreciated for years based on conventional isolation programs – and have helped set the foundation for a new natural product discovery paradigm based on genome mining. Trends in the secondary metabolomes of natural product-rich actinomycetes are highlighted in this review article, which contains 199 references.

Subfields: Biotechnology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d7158ff68cb54d1e116dadadaaacc8e384115788

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. D. Newman
2. G. Cragg
3. Leonard Katz
4. R. H. Baltz
5. B. Moore
6. W. Gerwick

In Pharmacology

1. G. Cragg
2. D. Newman
3. Leonard Katz
4. R. H. Baltz
5. A. Harvey
6. M. Gordaliza

Citations in the corpus

• NATURAL PRODUCTS: A CONTINUING SOURCE OF NOVEL DRUG LEADS (2013, background): “Coupled with the initial report of the sequencing of the marine actinomycete, Salinispora tropica, where it was found that approximately 10 percent of the genome coded for potential secondary metabolites [123, 124], and the paper on cultivation of Gram-positive marine microbes by the same group [125”
• PRISM 3: expanded prediction of natural product chemical structures from microbial genomes (2017, background): “Despite a decline in natural product discovery from a ‘golden age’ in the middle of the 20th century, genome sequencing indicates that the majority of genetically encoded natural products remain unknown (2,3).”
• Lessons from the past and charting the future of marine natural products drug discovery and chemical biology (2012, background): “Among these, fluorosalinosporamide displays potent “slowly reversible” proteasome inhibitory activity (Eustaquio and Moore, 2008), while the cyclopentenyl derivative salinosporamide X7 exhibits superior in vivo activity (Nett et al., 2009).”
• Natural product discovery: past, present, and future (2016, background): “Among the actinomycetes, the number of SMGCs varies widely [14, 84], and actinomycetes with very large genomes tend to be the most “gifted” [17, 19].”