Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome

By S. Lyapina, G. Cope, Andrej Shevchenko, G. Serino, T. Tsuge, Chunshui Zhou, D. Wolf, N. Wei, R. Deshaies. Science, 2001

713 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d69ca46076f08843c30a08308b9c08fb8fc74aca

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Citations in the corpus

• CSN controls NF‐κB by deubiquitinylation of IκBα (2007, background): “Cullin 1 (Cul1) and all other cullins identified so far (Lyapina et al, 2001; Schwechheimer et al, 2001; Zhou et al, 2001; Groisman et al, 2003; Liu et al, 2003; Pintard et al, 2003) represent the best-characterised substrates for dened- dylase activity of the CSN.”
• Understanding the functions of plant disease resistance proteins. (2003, background): “The COP9 multiprotein complex is involved in protein degradation through the 26S proteasome, which directly interacts with SCF E3 ubiquitin ligases (109, 157).”
• Multiple associated proteins regulate proteasome structure and function. (2002, methodology): “At this stage, the proteasome is essentially pure between the ubiquitin-like protein Rub1/Nedd-8 and its electrophoretically and may be eluted using TEV protease or used target proteins (Lyapina et al., 2001).”
• The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (2003, background): “Given that the recombinantgation of the NEDD8 from cullin family members (Lyapina et al., 2001; Yang et al., 2002).”
• The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. (2002, background): “…component of SCF complexes (Lammer et al., 1998; del Pozo and Estelle, 1999; Gray et al., 1999), and this RUB modification of Cdc53/cullin is important in regulating the activity of SCF ubiquitin ligases (del Pozo and Estelle, 1999; Osaka et al., 2000; Podust et al., 2000; Lyapina et al., 2001).”
• The ubiquitin–26S proteasome system at the nexus of plant biology (2009, background): “More specifically, a ring of six RP triple A (AAA + ) ATPases (RPTs 1–6) covers the opening to the CP and probably assists in target unfolding, the RP non-ATPases (RPNs) 10 and 13 are ubiquitin receptors, and RPN11 is a deubiquitylating enzyme (DUB) that helps to release bound ubiquitin”
• A cryptic protease couples deubiquitination and degradation by the proteasome (2002, background): “The CSN recently was shown to contain a deconjugation activity specific for the ubiquitin-like protein Nedd8 (ref”