Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.

By S. Shi, L. Jan, Y. Jan. Cell, 2003

625 citations recorded by the source corpus.

Subfields: Aging, Cell Biology, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/d677b6593c016790e11dc185683fb9829e30a758

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. A. Ridley

In Cell Biology

1. Cecilia Conde
2. A. Cáceres
3. Alan Hall
4. A. Jaffe
5. Kozo Kaibuchi
6. S. Newey
7. N. Arimura
8. L. Van Aelst

In Cellular and Molecular Neuroscience

1. Cecilia Conde
2. A. Cáceres
3. Kozo Kaibuchi

Citations in the corpus

• Rho GTPases: biochemistry and biology. (2005, background): “Cdc42 and the Par3/Par6/aPKC complex are specifically enriched in the developing axon and disruption of their activity results in polarity defects, leading to zero or multiple axons (Schwamborn & Puschel 2004, Shi et al. 2003).”
• Neuronal polarity: from extracellular signals to intracellular mechanisms (2007, background): “Accumulating evidence indicates the importance of PI3K and its lipid product, phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P 3 ), in neuronal polarizatio”
• Microtubule assembly, organization and dynamics in axons and dendrites (2009, background): “PI3K signalling also plays an important part in neuronal polarizatio”
• Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways (2005, background): “DOI:10.1523/JNEUROSCI.2284-05.2005 Copyright © 2005 Society for Neuroscience 0270-6474/05/2511288-12$15.00/0 tion of neuronal polarity and axonal growth (Markus et al., 2002; Shi et al., 2003; Jiang et al., 2005) have been revealed.”
• The role of the Rho GTPases in neuronal development. (2005, background): “2002), it was suggested that a positive feedback loop may amplify growth cone signaling to break the symmetrical distribution of mPar proteins and promote neuronal polarization (Shi et al. 2003).”
• The PAR proteins: fundamental players in animal cell polarization. (2007, background): “Also, dominant-interfering fragments of PAR-3, or inhibition of aPKC, can block axon specification (Shi et al., 2003).”