Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells.

By H. Robins, P. Campregher, S. Srivastava, A. Wacher, C. Turtle, Orsalem J. Kahsai, S. Riddell, E. Warren, C. Carlson. Blood, 2009

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Quantifying lymphocyte receptor diversity (2016, positive): “This bound has since been revisited using high-throughput sequencing data, yielding the same order of magnitude of a few millions [2, 3].”
Diversity and clonal selection in the human T-cell repertoire (2014, background): “(13) inferred the number of unseen TCRB genes from deep sequencing data by applying a Poisson process model and estimated a diversity of 3–4 million TCRB sequences in the total T-cell populations of two healthy donors.”
The Where, the When, and the How of Immune Monitoring for Cancer Immunotherapies in the Era of Checkpoint Inhibition (2016, methodology): “This approach uses the ability of T cells to recognize different peptides by the complementarity determining region 3 (CDR3) of the TCR and examines the overall changes in the TCR repertoire seeking to identify clonotypes that carry a given Vb-CDR3-Jb sequence (36).”
Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab (2017, methodology): “(Carlson et al., 2013; Robins et al., 2009), where targeted amplicon libraries were prepared by multiplex PCR targeting all TCR β-chain V and J gene segments, and sequenced using the Illumina HiSeq system.”
Multiple early factors anticipate post-acute COVID-19 sequelae (2022, positive): “High-throughput TCR b sequencing were performed as previously reported (Carlson et al., 2013; Chapuis et al., 2019; Robins et al., 2009).”