Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.

By Mihea G Netea, C. Nold-Petry, M. Nold, L. Joosten, B. Opitz, J. V. D. Meer, F. Veerdonk, G. Ferwerda, B. Heinhuis, I. Devesa and 6 more. Blood, 2009

842 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/d65851c2a6905ae909db612e7750d188f1bda10b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. T. Kanneganti
2. G. Núñez
3. C. A. Dinarello
4. J. Tschopp
5. Yuan He
6. S. Man
7. Greta Guarda
8. H. Hara

In Molecular Biology

1. T. Kanneganti
2. G. Núñez
3. C. A. Dinarello
4. Yuan He
5. S. Man
6. J. Tschopp
7. H. Hara
8. Greta Guarda

In Pulmonary and Respiratory Medicine

1. C. A. Dinarello

Citations in the corpus

• Human Monocytes Engage an Alternative Inflammasome Pathway. (2016, neutral): “This LPS-dependent inflammasome response was also observed in isolated human monocytes, which constitute the main source for IL-1b within PBMCs (Netea et al., 2009).”
• The inflammasome: an integrated view (2011, background): “However, it can also be envisaged that particular cell types expressing high levels of NLRP3 could be more susceptible to inflammasome activation or even harbor basal levels of active caspase-1, as is the case for human monocytes (17).”
• Regulation of inflammasome activation (2015, background): “Only the first signal is required for IL-1b secretion in human monocytes, possibly owing to the expression of constitutively active caspase-1 in these cells (48).”
• Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes (2012, methodology): “Because human monocytes exhibit constitutive caspase-1 cleavage and inflammasome activation (25), we assessed the activation of caspase-1 and IL1b in MDMs.”
• Mechanism and regulation of NLRP3 inflammasome activation (2016, background): “Alternative NLRP3 Inflammasome Pathway Human monocytes, unlike macrophages, are able to release mature IL-1b in response to TLR ligands alone, such as LPS [29,72].”
• TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling (2020, background): “In addition, in human and porcine monocytes (but not in murine cells), LPS induces NLRP3 activation and IL-1β release without the second stimulus [114].”
• Anti-inflammatory Agents: Present and Future (2010, positive): “The purinergic receptor P2X7 is activated by extracellular ATP and appears to be a critical early step in the release of active IL-1b (Netea et al., 2009; Perregaux et al., 2000).”