ATP as a biological hydrotrope

By L. Malinovska, Shambaditya Saha, Jie Wang, S. Alberti, Y. Krishnan, Anthony A. Hyman. Science, 2017

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Liquid phase condensation in cell physiology and disease (2017, background): “However, global ATP depletion influences material states of the entire cytoplasm (113, 114), potentially through its functions as a solubilizing intracellular hydrotrope (115), further underscoring the multifaceted role of ATP in intracellular fluidization.”
Liquid-Liquid Phase Separation in Disease. (2019, background): “, solubilizing agent) and prevents phase separation of RNA-binding proteins and even dissolves protein aggregates (65, 124).”
Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease (2017, background): “showed that ATP functions as a “hydrotrope” [106, 107].”