Polymer physics of intracellular phase transitions

By C. Brangwynne, Peter Tompa, Rohit V. Pappu. Nature Physics, 2015

1,350 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d60b00d3a715751c675fc03f5321a8039740021d

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Citations in the corpus

Distinct stages in stress granule assembly and disassembly (2016, background): “…class of non-membrane bound organelles and are thought to represent multicomponent viscous liquid droplets that from spontaneously by liquid-liquid phase separation (LLPS) (Brangwynne, 2013; Brangwynne et al., 2009, 2015; ElbaumGarfinkle et al., 2015; Hyman and Simons, 2012; Hyman et al., 2014).”
Protein Phase Separation: A New Phase in Cell Biology (2018, background): “Interestingly, these residues do not seem to be distributed randomly throughout the sequence, but are often found as short linear interaction motifs (SLiMs), alternating charge blocks, or degenerate repeats [50,51].”
Stress-triggered phase separation is an adaptive, evolutionarily tuned response (2017, background): “Previous work has focused on the roles of aromatic and charged-residue interactions in promoting IDR-mediated phase separation (Brangwynne et al., 2015).”
Sequence determinants of protein phase behavior from a coarse-grained model (2017, background): “This supports the hypothesis that fundamental polymer physics 47 principles can be used to understand LLPS [40].”
Random-phase-approximation theory for sequence-dependent, biologically functional liquid-liquid phase separation of intrinsically disordered proteins (2016, methodology): “as noted recently in the context of IDP phase separation [33].”
Liquid phase condensation in cell physiology and disease (2017, methodology): “These residues pattern the polypeptide backbone to enable charge-charge, charge-p, and p-p stacking interactions (30).”
Pi-Pi contacts are an overlooked protein feature relevant to phase separation (2018, background): “We recognize that multiple physical interactions can con- tribute to driving phase separation (Brangwynne et al., 2015), but our goal was not to predict sub- tle differences in phase separation propensity or quantitative phase diagrams.”
Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome. (2018, positive): “LLPS also appears to underlie nuclear body biogenesis, including nucleoli (Brangwynne et al., 2011; Feric et al., 2016; Mitrea et al., 2016), and likely many others (Zhu and Brangwynne, 2015).”
Intrinsically disordered regions contribute promiscuous interactions to RNP granule assembly (2017, methodology): “First, some experiments in vitro suggest that IDRs promote LLPS via weak binding, utilizing electrostatic, cation-π, dipole-dipole and π-π stacking interactions (Brangwynne et al., 2015; Lin et al., 2016; Nott et al., 2015; Pak et al., 2016).”
Phase separation in biology; functional organization of a higher order (2016, neutral): “(reviewed in [64]; Fig.”