The skin microbiome
By Elizabeth A. Grice, J. Segre. Nature Reviews Microbiology, 2011
882 citations recorded by the source corpus.
The skin is the human body's largest organ, colonized by a diverse milieu of microorganisms, most of which are harmless or even beneficial to their host. Colonization is driven by the ecology of the skin surface, which is highly variable depending on topographical location, endogenous host factors and exogenous environmental factors. The cutaneous innate and adaptive immune responses can modulate the skin microbiota, but the microbiota also functions in educating the immune system. The development of molecular methods to identify microorganisms has led to an emerging view of the resident skin bacteria as highly diverse and variable. An enhanced understanding of the skin microbiome is necessary to gain insight into microbial involvement in human skin disorders and to enable novel promicrobial and antimicrobial therapeutic approaches for their treatment.
Subfields: Dermatology, Epidemiology
View Paper: https://www.semanticscholar.org/paper/5ae185b50213e0a482fbd9967511eb0a222e48dd
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In Dermatology
In Epidemiology
Citations in the corpus
- Biogeography and individuality shape function in the human skin metagenome (2014, background): “The theta coefficient assesses the similarity between two samples based on (1) number of features in common between two samples, and (2) their relative abundances with θ=0 indicating totally dissimilar communities and θ=1 identical communities.”
- Temporal Stability of the Human Skin Microbiome (2016, neutral): “…community composition and function: the physiologic characteristics of a skin site, including pH, temperature, moisture, sebum content, and topography, shape the local microbial community (Costello et al., 2009; Findley et al., 2013; Grice et al., 2009; Grice and Segre, 2011; Oh et al., 2014).”
- Holobionts as Units of Selection and a Model of Their Population Dynamics and Evolution (2018, background): “…examining bacterial diversity have shown that skin microbiota is dependent on the body site, with specific bacteria being associated with moist, dry, and sebaceous microenvironments (Grice and Segre 2011), and different regions of the gut house different microbial communities (Donaldson et al.”