The conformational plasticity of protein kinases.

By M. Huse, J. Kuriyan. Cell, 2002

1,687 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d6041020ccc2ccf86972537c49a1aa840e97071e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. R. Roskoski
2. Christine Lovly
3. Z. Du
4. Jean-Pierre Eckmann
5. Tsvi Tlusty
6. Albert Libchaber
7. S. Dutta

In Molecular Biology

1. R. Roskoski
2. R. Youle
3. P. Czabotar
4. A. Strasser
5. M. Lazarou
6. D. Komander
7. Christine Lovly
8. Z. Du

Citations in the corpus

• The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. (2013, background): “Typically, in active protein kinases, this conserved Lys is positioned by a conserved Glu (E91 in cAMP-dependent protein kinase, PKA; E239 in MLKL) present on helix aC (Huse and Kuriyan, 2002; Taylor et al., 2012).”
• The ErbB/HER family of protein-tyrosine kinases and cancer. (2014, background): “Although the tertiary structure of catalytically active protein kinase domains are strikingly similar, Huse and Kuriyan reported that the crystal structures of dormant enzymes reveal a multitude of distinct inactive protein kinase conformations [47].”
• Green function of correlated genes in a minimal mechanical model of protein evolution (2018, methodology): “The two expressions for the mutation impact δG, [6] and [12], are equivalent and one may get the scattering series of [6] by a series expansion of the pseudo-inverse in [12].”
• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation (2003, background): “Protein kinases are generally restrained in an inactive state with the acquisition of catalytic activity controlled at multiple levels, ranging from the binding of allosteric factors to changes in the subcellular localization of the enzym”
• Plant recognition of symbiotic bacteria requires two LysM receptor-like kinases (2003, background): “The carboxy terminus of the NFR1 protein contains motifs associated with functional serine/threonine kinase”
• Mechanism of activation and inhibition of the HER4/ErbB4 kinase. (2008, background): “The ErbB4 kinase in these crystals adopts an inactive-like conformation (Figure 1B) (Huse and Kuriyan, 2002).”
• Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin (2012, background): “A PINK1 dimer may be associated with TOM as PINK1 can interact with itself (Liu et al., 2009), and kinases often function as dimers (Huse and Kuriyan, 2002).”
• Mechanisms of receptor tyrosine kinase activation in cancer (2018, positive): “FGFR, IR, and IGF-1R receptors are autoinhibited by the activation loop, which directly contacts the active site of the kinase and disrupts ATP and substrate binding [21, 22].”