Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

By L. Gorelik, R. Flavell. 2000

937 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d5c3875ca36cc50658737927fb28bc5742b2b9ef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. J. Massagué
2. P. ten Dijke
3. David A. Baker
4. Y. Hao
5. J. López-Novoa
6. M. Nieto
7. Bali Pulendran
8. R. Flavell

In Molecular Biology

1. J. Massagué
2. P. ten Dijke
3. R. Flavell
4. M. Nieto
5. D. Sheppard
6. David A. Baker
7. Y. Hao
8. Shomyseh Sanjabi

Citations in the corpus

• Inflammation and EMT: an alliance towards organ fibrosis and cancer progression (2009, background): “…as TGF-b1 knockout mice suffer from a lethal multifocal inflammatory disease (Kulkarni et al, 1993; Letterio & Roberts, 1998) and the blockage of TGF-b1 signalling in T cells or in bone marrow results in similar multifocal inflammatory responses (Gorelik & Flavell, 2000; Shull et al, 1992).”
• Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. (2001, background): “Abrogation of TGF-β1 signaling in T cells alone is sufficient to break T and B cell homeostasis and induce T cell–mediated inflammatory lesions in various organs, including the intestine (28).”
• TGF-beta: a master of all T cell trades. (2008, neutral): “cells, demonstrated a specific disturbance of T cell homeostasis or tolerance in the absence of TGF-β signaling (Gorelik and Flavell, 2000; Lucas et al., 2000).”
• Mechanisms of immune evasion by tumors. (2006, background): “Interestingly, a majority of these effects seem to be T‐cell mediated, as targeted disruption of T cell TGF‐b signaling also results a similar autoimmune phenotype (Gorelik and Flavell, 2000).”
• TGF-β Activation and Function in Immunity (2013, background): “Gorelik L, Flavell RA.”
• TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance (2005, neutral): “When challenged with TGF-β - producing tumors, mice whose T cells have been made resistant to TGF-β by expression of a dominant-negative TGF-β receptor transgene are able to mount an immune response, eliminate the tumor burden, and survive (Gorelik and Flavell, 2000, 2001).”