The Steap proteins are metalloreductases.
By R. Ohgami, D. Campagna, A. Mcdonald, M. Fleming. Blood, 2006
692 citations recorded by the source corpus.
Subfields: Genetics, Hematology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/d59a186f9b64ed0cacd6100efa6e41f7ad82ac1b
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
In Hematology
In Nutrition and Dietetics
Citations in the corpus
- Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates (2012, positive): “STEAP2 is known to play a role in maintaining homeostasis of iron and copper—metals that serve as essential components of the mitochondrial respiratory chain (Ohgami et al., 2006).”
- Iron uptake mechanisms in plants: Functions of the FRO family of ferric reductases (2009, background): “As mentioned above, yeast FRE6 and mammalian STEAP1-4 localize to internal membranes and function as ferric chelate reductases [47–59].”
- Cuproptosis: mechanisms and links with cancers (2023, background): “After being transported to the cell surface in the blood, divalent copper ions are reduced to monovalent copper ions catalyzed by steap proteins [32], which are bound and maintained in the reduced state by two His-Met-Asp clusters at the nitrogen terminus of CTR [33], and thus transported into the c”
- Mechanisms for copper acquisition, distribution and regulation. (2008, background): “The recent identification of a family of metalloreductases in humans—the Steap proteins, which are localized to both the plasma membrane and intracellular membranes—suggests the possibility that human Ctr1 might also function in concert with a metalloreductase for Cu 1+ movement across membrane”