Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study.

By M. Zaborowski, L. Balaj, X. Breakefield, C. Lai. BioScience, 2015

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Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “Although the lipid composition of MVs is highly similar to that of their donor cell, vesicles are unique in being enriched for polyunsaturated glycerophosphoserine and phosphatidylserine (Bicalho et al. 2013; Zaborowski et al. 2015).”
A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option? (2020, background): “(3) Polyethylene glycol (PEG) based precipitation uses a”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “However, in some cases, exosomes, depending on their size and shape, cannot be distinguished using this method because of exaggerated fluorescence signals [112].”
Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis (2019, methodology): “The uniqueness of EVs is that they have the ability to package active cargo (proteins, nucleic acids, and lipids) and deliver it to another cell, neighboring or distant, and alter the recipient cell’s functions with its delivery [1].”