Bone quality--the material and structural basis of bone strength and fragility.

By E. Seeman, P. Delmas. New England Journal of Medicine, 2006

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An overview and management of osteoporosis. (2017, background): “Bone mineral density can be easily measured to detect bone density, but the degree of deterioration of the bone tissue cannot be measured in clinical settings, except for the biochemical markers of bone tissue (27).”
From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. (2010, background): “Osteocytes, the bone cells with by far the most extensive lifespan, choreograph the process of bone remodeling by the short-lived osteoclasts and osteoblasts (362, 363).”
Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus (2010, background): “These are regulated by cellular activities and tissue turnover rate [1].”
Uncertainty in the niches that maintain haematopoietic stem cells (2008, background): “Osteoblasts and osteoclasts are present in dynamic equilibrium under steady-state conditions but can increase or decrease in frequency depending on whether bone is being formed or remodelle”