AKAP-Lbc Anchors Protein Kinase A and Nucleates Gα12-selective Rho-mediated Stress Fiber Formation*
By D. Diviani, J. Soderling, J. Scott. Journal of Biological Chemistry, 2001
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Guanine nucleotide exchange factors of the Dbl family relay signals from membrane receptors to Rho family GTPases. We now demonstrate that a longer transcript of the Lbc gene encodes a chimeric molecule, which we have called AKAP-Lbc, that functions as an A-kinase-anchoring protein (AKAP) and a Rho-selective guanine nucleotide exchange factor. Expression of AKAP-Lbc in fibroblasts favors the formation of stress fibers in a Rho-dependent manner. Application of lysophosphatidic acid or selective expression of Gα12 enhances cellular AKAP-Lbc activation. Furthermore, biochemical studies indicate that AKAP-Lbc functions as an adaptor protein to selectively couple Gα12 to Rho. Thus, AKAP-Lbc anchors PKA and nucleates the assembly of a Rho-mediated signaling pathway.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d516dcbe250d8868616a82ec2644c4e4d19c4dd6
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Citations in the corpus
- AKAP signalling complexes: focal points in space and time (2004, background): “Analogous signalling networks participate in the formation of actin STRESS FIBRES , as AKAP-Lbc, which is a longer transcript of the Lbc oncogene, anchors PKA and functions as a Rho-selective GUANINE NUCLEOTIDE-EXCHANGE FACTOR (GEF”