Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands.

By Roshan Cools, Roger A. Barker, Barbara J. Sahakian, Trevor W. Robbins. Cerebral Cortex, 2001

950 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/d501e827b0aa707706188d047b96802faef32d27

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Citations in the corpus

The cognitive functions of the caudate nucleus. (2008, background): “…al., 1996) in the striatum (Hornykiewicz, 1974), the Page 21 of 47 Ac ce pt ed M an us cr ip t 21 authors suggested that the observed effects on task set-shifting and reversal learning are most likely due to effects of dopamine in the dorsal and ventral striatum, respectively (Cools et al., 2001).”
Dynamic Dopamine Modulation in the Basal Ganglia: A Neurocomputational Account of Cognitive Deficits in Medicated and Nonmedicated Parkinsonism (2005, methodology): “The damaged BG in PD likely causes slowed learning observed in patients, just as it has been implicated as a source for habit learning deficits in the motor domain (e.g., Thomas-Ollivier et al., 1999; Soliveri, Brown, Jahanshahi, Caraceni, & Marsden, 1997).”
Dopamine, Affordance and Active Inference (2012, background): “We hypothesised that this would result in a failure of set switching and the perseveration of sensorimotor dynamics of the sort seen in Parkinson’s disease [7], [62], [63].”
The role of prefrontal cortex in cognitive control and executive function (2021, background): “In patients with Parkinson’s disease, therapeutic doses of L-Dopa appear to improve working memory and task-set switching but impair reversal learning and decision-making [130].”
Defining the Neural Mechanisms of Probabilistic Reversal Learning Using Event-Related Functional Magnetic Resonance Imaging (2002, background): “…(L-DOPA) doses, necessary to remediate the dopamine depletion in the dorsal striatum and its connections to the dorsolateral PFC, may detrimentally overdose relatively intact brain regions, such as the VS and its connections to the ventral PFC (Gotham et al., 1988; Cools et al., 2001).”
Dopamine and the regulation of cognition and attention. (2002, background): “…be speculated that doses of l-DOPA necessary to improve motor aspects of PD also contribute to facilitate DA transmission in dorsolateral-parietal cortical areas, but may " overdose any area where DA regions are relatively intact " , such as the orbitofrontal cortical areas (Cools et al., 2001).”
Evolution of cognitive dysfunction in an incident Parkinson's disease cohort. (2007, background): “Performance is typically influenced by both levodopa therapy (Lange et al., 1992; Owen et al., 1995a; Cools et al., 2001) and functional polymorphisms in genes involved in dopamine regulation (Foltynie et al.”
Neural correlates of rapid reversal learning in a simple model of human social interaction (2003, background): “…has also recently been shown that administration of dopaminergic medication to patients with mild Parkinson's disease has a detrimental effect on probabilistic reversal learning by effectively overdosing a relatively intact ventral frontostriatal system (Cools et al., 2001; Swainson et al., 2000).”
Hold your horses: A dynamic computational role for the subthalamic nucleus in decision making (2006, positive): “…& Robbins, 2001a; Shohamy et al., 2005; Swainson et al., 2000), it actually impairs performance in probabilistic reversal learning (Cools, 2005; Cools et al., 2001a; Swainson et al., 2000), that is when having to make decisions that require learning to overriding previously adaptive responses…”