Identification and characterization of tumorigenic liver cancer stem/progenitor cells.

By Stephanie Ma, K. Chan, Liang Hu, T. Lee, J. Wo, I. Ng, B. Zheng, X. Guan. Gastroenterology, 2007

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Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, methodology): “Based on previous published reports regarding CSCs in solid tumors [7–21], the following markers were studied: CD24, CD44, CD133, and CD166.”
CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway (2008, methodology): “A total of 5 104 CD133þ cells isolated from Huh7 human HCC cell line were injected subcutaneously into nude mice, as previously described (Ma et al., 2007).”
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. (2012, neutral): “Similarly, the expression of various selected oncofetal genes, namely Afp , Igf2 , and Src , together with the cancer stem cell marker genes Prom1 , Thy1 , and Epcam , could be first detected in the livers of young Mir122a –/– mice, and this was followed by further increases in the expression of the”