Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors

By A. Chenn, C. Walsh. Science, 2002

1,456 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d4f2e73a464ebba414aae27ef97af731cd594c57

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In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. A. Kriegstein
4. S. Morrison
5. W. Huttner
6. M. Clarke
7. S. Angers
8. Juergen A. Knoblich

Citations in the corpus

• β-Catenin signaling is required for neural differentiation of embryonic stem cells (2004, background): “…of constitutively active β-catenin in neural stem cells increased neurogenesis primarily by decreasing cell cycle exit of neural progenitors (Chenn and Walsh, 2002), and β-catenin expression in the developing spinal cord maintained neural progenitor cells in a proliferative state with…”
• β-catenin is critical for dendritic morphogenesis (2003, positive): “Specifically, overexpression of β-catenin increases cortical size by regulating the generation of neural precursor”
• Early brain development in infants at high risk for autism spectrum disorder (2017, positive): “Cellular mechanisms and heritability underlying SA expansion are thought to differ from mechanisms underlying cortical thickness 17,18 , and SA hyper-expansion has been reported in genetically-engineered mouse models of autism 19 .”
• Cell-cycle control and cortical development (2007, background): “Mutations of genes that interfere with the switch between proliferative symmetrical divisions and differentiative asymmetrical divisions in the VZ have been shown to affect cortical siz”
• Technical innovations drive the relationship between innovativeness and residual brain size in birds (2009, neutral): “…networks (Green et al. 2009) and whole brain size (Evans et al. 2005; Mekel-Bobrov et al. 2005) as well as developmental schedules of embryonic neurogenesis leading to differences in the whole telencephalon (Striedter & Charvet 2008, 2009) and cortex (Chenn & Walsh 2002) have been identified.”
• An essential switch in subunit composition of a chromatin remodeling complex during neural development. (2007, background): “BAF45a but Not BAF45b Is Sufficient to Enhance Neural Progenitor Proliferation To further study the role of the newly identified progenitorspecific BAF45a subunit in regulating neural stem/progenitor function, we generated transgenic mice expressing BAF45a or the homologous BAF45b under the control ”
• Emerging roles of Wnts in the adult nervous system (2010, background): “During development Wnts act on CNS progenitor cells, and the activation of β-catenin leads to the proliferation of the neural progenitor pool, resulting in the expansion of the entire neural tub”
• Evolution of the neocortex: Perspective from developmental biology (2009, neutral): “For example, the β-catenin-mediated signalling pathway acts on the decision of the neuronal precursor cells to exit the cell cycl”