Role of cell cycle in mediating sensitivity to radiotherapy.

By T. Pawlik, K. Keyomarsi. International Journal of Radiation Oncology, Biology, Physics, 2004

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A Consensus Molecular Classification of Muscle-invasive Bladder Cancer (2019, background): “In contrast, NE-like and LumU tumors both had profiles associated with a potential response to radiotherapy [32,33], showing elevated cell cycle activity (pNElike< 0.”
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy (2015, background): “It was shown that cells exposed to ionizing radiation are the least sensitive at the end of S phase, less sensitive in the G1 phase, and the most radiosensitive in the G2/M phase where DNA repair mechanisms are the most prone to malfunction.(100) Hence, anticancer treatments, both radio- and chemoth”
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements☆ (2017, background): “While cells in late G2 andmitosis are the most radiosensitive, cells in late S phase are themost radioresistant [103].”