Mechanisms of spreading depression and hypoxic spreading depression-like depolarization.

By G. Somjen. Physiological Reviews, 2001

1,146 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d48aa907436277ab75b2c00c6f89ae8bf601c6e4

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

Regional blood flow in the normal and ischemic brain is controlled by arteriolar smooth muscle cell contractility and not by capillary pericytes (2015, positive): “To determine the precise location within the vascular tree of CSD-induced vasomotor responses, we loaded neural cells with the calcium-sensitive dye Oregon Green Bapta 1AM (OGB) in SMA-mCherry transgenic mice that had been intravenously injected with a fluorescent dye to visualize the vessel lumen (”
Thermal stress and neural function: adaptive mechanisms in insect model systems (2004, background): “The ionic disturbance associated with the failure of the ventilatory CPG in locusts is very similar to disturbances associated with spreading depression in mammalian cortex (Somjen, 2001, 2002).”
Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury (2011, background): “2 to 0.1 to 0.2 mmol/L, [CI ] decreases from 120 to 50 to 70 mmol/L, and [Na+] decreases from 150 to 50 to 70 mmol/L (Kraig and Nicholson, 1978; Somjen, 2001).”
Pathophysiology of Migraine: A Disorder of Sensory Processing. (2017, background): “It is now clear through a number of excellent studies that CSD results from the depolarization, followed by a sustained hyperpolarization [or quiescence (512, 513)] of neurons and glial cells with almost a complete reversal of membrane potential resulting in breakdown of normal ionic gradients (743)”
The Impact of Astrocytic Gap Junctional Coupling on Potassium Buffering in the Hippocampus (2006, background): “If K regulation fails, pathological events such as spreading depression, anoxic depolarization, and epileptiform activity may be initiated (Somjen, 2001; Seifert et al., 2006).”
Conditional Knock-Out of Kir4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation (2007, background): “However, prolonged exposure to high extracellular K can lead to a phenomenon called spreading depression marked by a decrease in neuronal excitability (Somjen, 2001).”
On the nature of seizure dynamics. (2014, background): “This DC shift is smaller ( 0.26 0.08 mV, n = 15 SLEs from five hippocampi, P5 0.01) and shorter lasting (1–3 min) than that found in spreading depression (Somjen, 2001).”
Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain (2013, background): “CSD is a slowly propagating wave (2–6 mm/min) of neuronal and glial depolarization followed by a prolonged inhibition (15– 30 minutes) of cortical activity [116,117].”
Laser speckle contrast imaging in biomedical optics. (2010, background): “than 50 yr and its role in the pathophysiology of stroke, migraine, and subarachnoid hemorrhage is well established.(61,62) Recent clinical studies have further emphasized the importance of SD in human stroke and brain injury.”
Cortical neural prosthetics. (2004, background): “Local changes in the extracellular concentration of potassium and calcium may silence the activity of nearby neurons through a local mechanism similar to spreading depression (Somjen 2001).”