Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

By M. Furuhashi, G. Hotamışlıgil. Nature reviews. Drug discovery, 2008

1,644 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d4862f64e12436e337929e4f23765ca93335a5ea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. G. Hotamisligil
2. M. Félétou

In Molecular Biology

1. E. Lengyel
2. G. Hotamisligil
3. Severine Vermeire
4. M. Vancamelbeke

Citations in the corpus

• Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review (2014, background): “Recent research strategies also explore targeting the nuclear factor-kappaB (NF-kB) pathway [8], mitogen-activated protein kinases (MAPK) signaling [9], fatty acid-binding proteins [10], as well as other targets involved in fatty acid metabolism [11,12].”
• Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels (2019, background): “It also is critical in inducing the uptake of glucose and fatty acids by the cells [31].”
• CARNITINE TRANSPORT AND FATTY ACID OXIDATION (2016, neutral): “FABP isoforms have tissuespecific expression and differ in stoichiometry, affinity, and specificity toward their ligands [49, 50].”
• Endothelial dysfunction and vascular disease – a 30th anniversary update (2017, background): “These include: (i) emergence of fatty acid-binding proteins (Furuhashi et al. 2007, Lee et al. 2007, Furuhashi & Hotamisligil 2008, Hoo et al. 2008) and matrixmetalloproteinase 7 (MMP7; Lee et al. 2007); (ii) circulating chemokines (Ardigo et al. 2007); (iii) inhibition of the proteosome (Herrmann…”
• The intestinal barrier: a fundamental role in health and disease (2017, background): “FABP are abundantly expressed proteins of 14–15 kDa that aid in the transport and signaling of fatty acids [31].”
• Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth (2011, background): “FABP4 reversibly binds long-chain fatty acids and is highly expressed in adipocyte”
• Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, neutral): “We recently demonstrated that lipid chaperones such as aP2 (Furuhashi and Hotamisligil, 2008) are crucial for linking toxic lipids such as saturated fatty acids or oxidized lipoproteins to ER stress and survival pathways (Erbay et al.”
• Free Fatty Acid Receptors in Health and Disease. (2020, background): “As the physiological sensors of FFAs, members of the intracellular or nuclear lipid-binding protein families, such as fatty acid binding proteins (FABPs) and peroxisome proliferator activated receptors (PPARs), are known as functional receptors that regulate many physiological and pathophysiological”
• Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism (2008, neutral): “Several FABPs have been reported to play critical roles in systemic metabolism ( Furuhashi and Hotamisligil, 2008 ).”
• What We Talk About When We Talk About Fat (2014, neutral): “A smallmolecule inhibitor of this fatty-acid-binding protein was found to ameliorate both insulin resistance and atherosclerosis in rodent models; the fact that these proteins evolved to bind small lipophilic ligandsmakes them particularly promising drug targets (Furuhashi and Hotamisligil, 2008).”