Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
By K. Nieman, H. Kenny, Carla V. Penicka, A. Ladányi, R. Buell-Gutbrod, M. Zillhardt, Iris L. Romero, Mark S Carey, Gordon B Mills, G. Hotamisligil and 4 more. Nature Medicine, 2011
2,091 citations recorded by the source corpus.
Subfields: Occupational Therapy, Pharmacology, Social Psychology
View Paper: https://www.semanticscholar.org/paper/ac2f57d51076c161d14e24b7611f59f67bdc5e1d
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In Occupational Therapy
In Pharmacology
- L. Galluzzi
- Alec C. Kimmelman
- Guido Kroemer
- Nikos Koundouros
- David M. Sabatini
- Craig B. Thompson
- G. Poulogiannis
- F. Balkwill
Citations in the corpus
- Adipose tissue and adipocytes supports tumorigenesis and metastasis (2013, background): “In an effort to understand why ovarian cancer metastasizes to the omentum we showed that primary human omental adipocytes induce breast, colon, and ovarian cancer cell proliferation and invasion in vitro and ovarian cancer growth in vivo [78].”
- Obesity and cancer risk: Emerging biological mechanisms and perspectives. (2019, background): “crete cytokines (IL-6 and IL-8), which result in increased migration and invasiveness of cancerous ovarian cells [130].”
- Mitochondrial metabolism and cancer (2017, background): “have been shown to obtain fatty acids for oxidative metabolism from local adipocytes, providing a support to tumor progression [132-135].”
- Loss of BRCA1 in the cells of origin of ovarian cancer induces glycolysis: A window of opportunity for ovarian cancer chemoprevention (2017, methodology): “Fatty acid oxidation was assessed using a previously described method (14), with minor modifications.”
- Cancer Cell Metabolism: One Hallmark, Many Faces (2012, background): “Studies reporting two-compartment tumor metabolism have recently emerged in the context of breast cancer cells and their neighboring fibroblasts (150, 151), as well as for ovarian cancer cells and their neighboring adipocytes (152).”