Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism

By Jian Q. Feng, L. Ward, Shiguang Liu, Yongbo Lu, Yixia Xie, Baozhi Yuan, Xijie Yu, F. Rauch, S. I. Davis, Shubin Zhang and 5 more. Nature Genetics, 2006

1,170 citations recorded by the source corpus.

Subfields: Genetics, Nephrology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/d4702bbcc772e41de253565a2d4949a47344f1b2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Clemens Bergwitz
2. H. Jüppner
3. Yangli Xie
4. N. Su
5. Jing Yang
6. Q. Tan
7. Shuo Huang
8. Jian Q. Feng

Citations in the corpus

• FGF/FGFR signaling in health and disease (2020, background): “Both DMP1 and PHEX knockout mice exhibit hypophosphatemic rickets and increased FGF23 expression.(594,596) Although PHEX is a peptidase expressed in the bone, it can inhibit the expression FGF23 without regulating FGF23 degradation.”
• Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23 (2010, background): “Conversely, increased FGF23 levels in most individuals affected by Xlinked hypophosphatemia (88), autosomal dominant hypophosphatemic rickets (56), or autosomal recessive hypophosphatemia (89, 90) leads to renal phosphate wasting.”