Gene therapy: trials and tribulations

By N. Somia, Inder M. Verma. Nature reviews genetics, 2000

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Nanomedicine: current status and future prospects (2005, background): “Although, viral vectors are extremely efficient delivery systems for nucleic acids, they can induce severe immunotoxicity as well as inadvertent gene expression changes after random integration into the host genome (151, 152).”
Non viral vectors in gene therapy- an overview. (2015, background): “The optimal vector and delivery system depends on the target cells and its characteristics, duration of expression and the size of the genetic material to be incorporated in the vector [3,4].”
Biology-inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing (2016, neutral): “…therapy 2004 / VIOXX 2006 / TGN1412 2016 / BIA 10-2474 Reference Fabro et al., 1965; Woollam, 1965; Bauer et al.,1998; Stephens and Fillmore, 2000 Somia and Verma, 2000; Edwards, 2004 Dieppe et al., 2004; Arbor, 2004 Clair, 2008; Stebbings et al., 2012 Jouan, 2016; Mileni et al., 2008 Adverse…”