Non viral vectors in gene therapy- an overview.

By Murali Ramamoorth, Aparna Narvekar. Journal of clinical and diagnostic research : JCDR, 2015

691 citations recorded by the source corpus.

Non-viral vectors are simple in theory but complex in practice. Apart from intra cellular and extracellular barriers, number of other challenges also needs to be overcome in order to increase the effectiveness of non-viral gene transfer. These barriers are categorized as production, formulation and storage. No one-size-fits-all solution to gene delivery, which is why in spite of various developments in liposome, polymer formulation and optimization, new compounds are constantly being proposed and investigated. In this review, we will see in detail about various types of non-viral vectors highlighting promising development and recent advances that had improved the non-viral gene transfer efficiency of translating from "Bench to bedside".

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/74fc4056d71593114c5ae7100e6dc1e17d440e20

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Citations in the corpus

• CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future (2020, background): “A concern is whether these methods can be optimized to provide equivalent efficiency of gene delivery to that provided by viruses (19).”