Global Illness and Deaths Caused by Rotavirus Disease in Children

By U. Parashar, Erik Hummelman, J. Bresee, Mark A. Miller, R. Glass. Emerging Infectious Diseases, 2003

2,029 citations recorded by the source corpus.

To estimate the global illness and deaths caused by rotavirus disease, we reviewed studies published from 1986 to 2000 on deaths caused by diarrhea and on rotavirus infections in children. We assessed rotavirus-associated illness in three clinical settings (mild cases requiring home care alone, moderate cases requiring a clinic visit, and severe cases requiring hospitalization) and death rates in countries in different World Bank income groups. Each year, rotavirus causes approximately 111 million episodes of gastroenteritis requiring only home care, 25 million clinic visits, 2 million hospitalizations, and 352,000–592,000 deaths (median, 440,000 deaths) in children <5 years of age. By age 5, nearly every child will have an episode of rotavirus gastroenteritis, 1 in 5 will visit a clinic, 1 in 60 will be hospitalized, and approximately 1 in 293 will die. Children in the poorest countries account for 82% of rotavirus deaths. The tremendous incidence of rotavirus disease underscores the urgent need for interventions, such as vaccines, to prevent childhood deaths in developing nations.

Subfields: Hepatology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/d3a3e23ba6939719b75ac3c98727e1c1843b053a

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Citations in the corpus

• Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine (2005, background): “Interestingly, the majority of these G8 human strains are not associated with the P[10] type, but present a great diversity of P-G combinations such as P[8]G8, P[4]G8, P[6]G8, P[1]G8, P[2]G8 and P[14]G8 [41,42,53,57–62,80,88,90,107,109], which is similar to those found in G9 type.”
• Global, regional, and national estimates of rotavirus mortality in children <5 years of age, 2000–2013 (2016, background): “Comparison of the current figures with our own previously published estimates of rotavirus mortality for the year 2004 and 2008 derived using the same methods is difficult [9, 24],”
• RotaC: A web-based tool for the complete genome classification of group A rotaviruses (2009, background): “000 deaths in children, mostly in the developing countries [1].”
• Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments (2008, background): “It is estimated that, globally, one in five cases will be presented to a doctor, 1 in 65 will require hospitalization, and 1 in 293 will die [27, 28, 39].”
• Rotavirus and Severe Childhood Diarrhea (2006, methodology): “In 2003, we published an estimate of rotavirus-related deaths worldwide based on a review of the literature published from 1986 through 1999 on deaths caused by diarrhea and rotavirus hospitalizations in children (2).”
• Systematic Literature Review of Role of Noroviruses in Sporadic Gastroenteritis (2008, neutral): “To calculate the number of outpatient NoV episodes and hospitalizations for children living in industrialized countries (where 23 of 31 studies in our review were conducted), we multiplied the total number of estimated diarrhea episodes in each clinical setting by the pooled proportion attributable ”
• Global Causes of Diarrheal Disease Mortality in Children <5 Years of Age: A Systematic Review (2013, result): “Such adjustments have not been done in previously published estimates for single diarrhea etiologies [4, 5, [10] [11] [12] .”