The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

By Tianpeng Gu, Fan Guo, Hui Yang, Hai-Ping Wu, Guiyong Xu, Wei Liu, Zhi-Guo Xie, Linyu Shi, Xinyi He, Seung-Gi Jin and 7 more. Nature, 2011

1,108 citations recorded by the source corpus.

Subfields: Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/d2ea842305a97d9067bd8b3fc055ca24876fcbef

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In Molecular Biology

1. Hao Wu
2. Yi Zhang
3. Feng Zhang
4. R. Jaenisch
5. Alexander Meissner
6. Wolf Reik
7. Chuan He
8. Aviv Regev

In Pediatrics, Perinatology and Child Health

1. Yi Zhang
2. Alexander Meissner
3. Hao Wu
4. Wolf Reik

Citations in the corpus

• WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation (2015, positive): “…have linked the function of Tet genes to various biological pathways, including zygotic, embryonic and perinatal development (Dawlaty et al., 2013; Gu et al., 2011), differentiation of haematopoietic cells (Ko et al., 2011; Li et al., 2011; Moran-Crusio et al., 2011; Quivoron et al., 2011), and…”
• Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome (2012, positive): “The TET proteins, which are responsible for conversion of 5mC to 5hmC, have been shown to function in ESC regulation, myelopoiesis and zygote development (Dawlaty et al., 2011; Gu et al., 2011; Iqbal et al., 2011; Ito et al., 2010; Ko et al., 2010; Koh et al., 2011; Wossidlo et al., 2011).”
• Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, positive): “Knockdown or deletion of TET3, the only 5mC oxidase present at this stage, abolished the loss of 5mC and 5hmC generation in the male pronucleus (Gu et al., 2011; Wossidlo et al., 2011).”
• Uncovering the role of 5-hydroxymethylcytosine in the epigenome (2011, background): “Expression of Tet3 is by far highest in oocytes and zygotes, where 5hmC levels rise dramatically after fertilization in the male pronucleus”
• One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering (2013, positive): “These results are consistent with the lethal neonatal phenotype of Tet3 knockout mice generated using traditional methods (Gu et al., 2011), although we have not yet established which of the Tet3 mutations produced loss of function rather than hypomorphic alleles.”
• A unique regulatory phase of DNA methylation in the early mammalian embryo (2012, background): “The feature-specific dynamics of DNA methylation at fertilization suggest that Tet3 and hmC may be required for targeted demethylation, as well as for driving a gradual hypomethylation over cleavage 9,10 .”
• Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011, background): “In addition, somatic cell nuclear transfer (SCNT) using Tet3-deficient oocytes, but not control oocytes, resulted in failure in 5mC oxidation of somatic genomes, impaired demethylation at the somatic Oct4 promoter, and activation of an Oct4-EGFP transgene (Gu et al. 2011).”