The evolutionary fate and consequences of duplicate genes.

By Michael Lynch, J. Conery. Science, 2000

4,699 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d26fb8e0b2caa249335511298084575600b09f39

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Citations in the corpus

A recent polyploidy superimposed on older large-scale duplications in the Arabidopsis genome. (2003, methodology): “…its sequence is that, like the Saccharomyces cerevisiae (Wolfe and Shields 1997) and human (Lander et al. 2001; Venter et al. 2001; Gu et al. 2002; McLysaght et al. 2002) genomes, it contains numerous large duplicated chromosomal segments (Arabidopsis Genome Initiative 2000; Blanc et al. 2000;…”
Gene Expression Programming: A New Adaptive Algorithm for Solving Problems (2001, background): “It is known that the duplication of genes plays an important role in biology and evolution (e.g., [ 11 ]).”
Genome-wide analysis of NAC transcription factor family in rice. (2010, background): “Lynch and Conery (2000) have found that during the course of evolution some of the alternative outcomes of duplicated genes have included (i) nonfunctionalization, (ii) neofunctionalization, and (iii) subfunctionalization.”
Plants with double genomes might have had a better chance to survive the Cretaceous–Tertiary extinction event (2009, background): “For instance, by assuming a rate of 6.1 10 9 synonymous substitutions per synonymous site per year, Lynch and Conery (17) dated the youngest genome duplication in Arabidopsis at 65 million years ago (mya) (see also SI Text).”
Genome evolution and biodiversity in teleost fish (2005, background): “This is consistent with the observation that, for the vast majority of gene duplicates, one copy evolves as a pseudogene through degenerative mutations (nonfunctionalization) and/or is eliminated because of its dispensability (Lynch and Conery (2000) and references therein).”
L. A. S. JOHNSON REVIEW No. 2 Use of nuclear genes for phylogeny reconstruction in plants (2004, background): “2000; Lynch and Conery 2000; Small and Wendel 2000a; Bancroft 200I; Gaut 200 I; Ford and Gottlieb 2002).”
Widespread genome duplications throughout the history of flowering plants. (2006, background): “results to analyses of all paralogous pairs (Fig. 2B; Lynch and Conery 2000; Blanc et al. 2003; Maere et al. 2005), suggesting that 6000 unigenes are sufficient for estimating Ks distributions for the other species in this study (Table 2).”
Similarities and Differences in Genome-Wide Expression Data of Six Organisms (2003, background): “Comparing the genomic sequences of different organisms presents an alternative prominent approach for gene annotation and identification of regulatory elements (Chervitz et al. 1998; Lynch and Conery 2000; Rubin et al. 2000; Yanai and DeLisi 2002; Frazer et al. 2003).”
RELAX: detecting relaxed selection in a phylogenetic framework. (2014, background): “After gene duplication, neofunctionalization and subfunctionalization may be facilitated by relaxation of selective constraints, followed by positive selection for previously inaccessible features (Lynch and Conery, 2000; Ohno, 1970).”
RNA-Seq Atlas of Glycine max: A guide to the soybean transcriptome (2010, background): “The generation of so many duplicated genes likely gave rise to a large number of new, novel and perhaps unique gene functions [4,5].”
More than the sum of their parts: On the evolution of proteins from peptides (2003, positive): “In each of these cases, the duplicated copies are freed from the selective pressure to maintain function and in fact come under pressure to assume a novel selectable function in order to avoid extinction through mutational inactivation.((9))”