Progressive multiple sclerosis: pathology and pathogenesis

By Hans Lassmann, J. Horssen, D. Mahad. Nature Reviews Neurology, 2012

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Multiple Sclerosis Pathology. (2018, background): “Based on knowledge from experimental models, there are many different immunological mechanisms that may be involved in this process, and the question arises, which of these mechanisms are relevant for MS (Lucchinetti et al. 2000; Lassmann et al. 2012).”
Clinical and Pathological Insights into the Dynamic Nature of the White Matter Multiple Sclerosis Plaque (2015, background): “Because chronic MS has been associated with compartmentalized inflammation and a decrease in inflammation over time, it seems surprising that shadow plaques are not more common among progressive MS patients with longstanding disease.(3,13) As previously described, this failure to remyelinate axons m”
Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis (2019, background): “The meningeal and perivascular infiltrates are associated with slow expansion of pre-existing focal white matter lesions, with subpial cortical demyelination and with diffuse damage of the normal appearing white and gray matter, which are the changes typically found in the brain and spinal cord of p”