Clinical and Pathological Insights into the Dynamic Nature of the White Matter Multiple Sclerosis Plaque

By J. Frischer, S. Weigand, Yong Guo, N. Kale, Joseph E. Parisi, I. Pirko, J. Mandrekar, S. Bramow, I. Metz, Wolfgang Brück and 2 more. Annals of Neurology, 2015

668 citations recorded by the source corpus.

An extensive analysis of white matter plaques in a large sample of multiple sclerosis (MS) autopsies provides insights into the dynamic nature of MS pathology.

Subfields: Neurology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/70643ac720ac226958e19be7ce5051c23a532446

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. Hans Lassmann
2. Wolfgang Brück
3. A. Prat

In Pathology and Forensic Medicine

1. Hans Lassmann
2. Wolfgang Brück

Citations in the corpus

• Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis (2019, background): “However, very large neuropathological studies on more than 300 patient autopsies did not reveal significant differences between PPMS and SPMS patients in the global extent of white matter plaques or the relative incidence of different focal white matter lesions, such as active, chronic active (slowl”
• An updated histological classification system for multiple sclerosis lesions (2016, background): “Inactive lesions are the dominating plaque type in patients with disease duration of more than 15 years and/or secondary progressive MS without attacks [23].”
• Multiple Sclerosis Pathology. (2018, background): “Such classical active lesions, described above, are mainly seen in patients who have died in early disease stages, such as acute MS or relapsing remitting MS (Frischer et al. 2015); they can be distinguished from slowly expanding active lesions, which are most frequently seen in patients with progre”