Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology.

By N. Abbott. Neurochemistry International, 2004

787 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Pediatrics, Perinatology and Child Health, Surgery

View Paper: https://www.semanticscholar.org/paper/d25dd6417d3cdf76e9b5574a3460ba2b8e7ef6b2

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In Cellular and Molecular Neuroscience

In Pediatrics, Perinatology and Child Health

In Surgery

Citations in the corpus

Structure and function of the blood-brain barrier. (2010, background): “, 2004), while the remainder of the brain extracellular fluid, the interstitial fluid (ISF), is derived at least in part by secretion across the capillary endothelium of the BBB (Cserr et al., 1981; Cserr and Patlak, 1992; Abbott, 2004; Dolman et al., 2005).”
Aquaporin‐4 facilitates reabsorption of excess fluid in vasogenic brain edema (2004, background): “Another proposed but controversial route for clearance of edema fluid is movement from brain parenchyma into Virchow-Robin perivascular spaces, which are CSF-filled spaces that communicate with the subarachnoid space (30).”
A new look at cerebrospinal fluid circulation (2014, background): “29 μl g brain min [30,61], reviewed by [29].”
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain (2009, background): “The brain not only lacks a defined lymphatic system but has very low levels of protein in the interstitial fluid, thus limiting fluid movement into the brain (Abbott 2004; Boulton et al. 1998; Weller et al. 2008).”
Diffusion in Brain Extracellular Space (2008, neutral): “Abbott (1) has provided a review of bulk flow.”
Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis. (2009, neutral): “Alafuzoff et al. (1983) 16 20 69± n/s 65± n/s 7.”
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β (2012, methodology): “Interstitial solutes have been thought to be cleared to the CSF by the convective bulk flow of ISF, which courses diffusely through brain tissue, rather than through an anatomically or functionally discrete structure (3, 4, 9).”
Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain (2013, background): “It has been widely accepted that paravascular spaces provide a pathway for the clearance of interstitial solutes from the brain parenchyma (Cserr and Ostrach, 1974; Ichimura et al., 1991; Yamada et al., 1991; Abbott, 2004).”