Inhibition of ethanol-producing yeast and bacteria by degradation products produced during pre-treatment of biomass

By H. Klinke, A. Thomsen, B. Ahring. Applied Microbiology and Biotechnology, 2004

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Economics and environmental impact of bioethanol production technologies: an appraisal (2007, background): “…temperatures (or longer residence time) are applied, the hemicelluosic derived monosaccharides will degrade and give rise to fermentation inhibitors like furan compounds, weak carboxylic acids and phenolic compounds (Olsson and Hahn- Hagerdal, 1996; Klinke et al., 2004; Larsson et al., 1999).”
Selection of thermotolerant yeast strains Saccharomyces cerevisiae for bioethanol production (2008, background): “The microorganisms employed in the fermentation of sugars from lignocellulose into ethanol are principally bacteria and yeasts [1,2].”
Towards industrial pentose-fermenting yeast strains (2007, background): “Also, the naturally pentosefermenting yeasts are generally inhibited by industrial substrates (Hahn-Hägerdal et al. 1991, 1994a; Olsson et al. 1992; Hahn-Hägerdal and Pamment 2004; Klinke et al. 2004) and do not grow under anaerobic conditions even on hexose sugars (Visser et al. 1990).”
Progress in Metabolic Engineering of Saccharomyces cerevisiae (2008, background): “have additive or synergistic effects (171).”