Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

By R. Anthony, F. Nimmerjahn, D. Ashline, V. Reinhold, J. Paulson, J. Ravetch. Science, 2008

841 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/d1d0687b5e5c79f46776e30cbd8ad2fe9b6d44cb

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In Hematology

1. J. Ravetch

In Molecular Biology

1. J. Ravetch
2. F. Nimmerjahn

In Radiology, Nuclear Medicine and Imaging

1. J. Ravetch
2. F. Nimmerjahn

Citations in the corpus

• IgG Subclasses and Allotypes: From Structure to Effector Functions (2014, background): “Increased sialylation of IgG generally follows increased galactosylation as galactosylated IgG is the substrate for sialyltransferases (Figure 1B) (54, 103, 126).”
• Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway (2011, background): “This anti-inflammatory activity of intravenous immunoglobulin is triggered by a minor population of IgG crystallizable fragments (Fcs), with glycans terminating in a2,6 sialic acids (sFc) that target myeloid regulatory cells expressing the lectin dendritic-cell-specific ICAM-3 grabbing non-integrin ”