Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia.
By Huaping Zhu, Lin Wang, Chengzhi Fang, S. Peng, Lianhong Zhang, Guiping Chang, S. Xia, Wenhao Zhou. Translational Pediatrics, 2020
1,238 citations recorded by the source corpus.
Background The newly identified 2019-nCoV, which appears to have originated in Wuhan, the capital city of Hubei province in central China, is spreading rapidly nationwide. A number of cases of neonates born to mothers with 2019-nCoV pneumonia have been recorded. However, the clinical features of these cases have not been reported, and there is no sufficient evidence for the proper prevention and control of 2019-nCoV infections in neonates. Methods The clinical features and outcomes of 10 neonates (including 2 twins) born to 9 mothers with confirmed 2019-nCoV infection in 5 hospitals from January 20 to February 5, 2020 were retrospectively analyzed. Results Among these 9 pregnant women with confirmed 2019-nCoV infection, onset of clinical symptoms occurred before delivery in 4 cases, on the day of delivery in 2 cases, and after delivery in 3 cases. In most cases, fever and a cough were the first symptoms experienced, and 1 patient also had diarrhea. Of the newborns born to these mothers, 8 were male and 2 were female; 4 were full-term infants and 6 were born premature; 2 were small-for-gestational-age (SGA) infants and 1 was a large-for-gestational-age (LGA) infant; there were 8 singletons and 2 twins. Of the neonates, 6 had a Pediatric Critical Illness Score (PCIS) score of less than 90. Clinically, the first symptom in the neonates was shortness of breath (n=6), but other initial symptoms such as fever (n=2), thrombocytopenia accompanied by abnormal liver function (n=2), rapid heart rate (n=1), vomiting (n=1), and pneumothorax (n=1) were observed. Up to now, 5 neonates have been cured and discharged, 1 has died, and 4 neonates remain in hospital in a stable condition. Pharyngeal swab specimens were collected from 9 of the 10 neonates 1 to 9 days after birth for nucleic acid amplification tests for 2019-nCoV, all of which showed negative results. Conclusions Perinatal 2019-nCoV infection may have adverse effects on newborns, causing problems such as fetal distress, premature labor, respiratory distress, thrombocytopenia accompanied by abnormal liver function, and even death. However, vertical transmission of 2019-nCoV is yet to be confirmed.
Subfields: Infectious Diseases, Modeling and Simulation, Obstetrics and Gynecology
View Paper: https://www.semanticscholar.org/paper/d18d860d972c6e146fd35fb08ba486b42c0a9ba6
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Citations in the corpus
- The SARS-CoV-2 outbreak: What we know (2020, background): “In addition, it has been reported that the mother was diagnosed with a new type of coronavirus pneumonia, and the newborn was positive for viral nucleic acid in pharynx swabs after 30 hours of birth([26]), suggesting that the new type of coronavirus may cause neonatal infection through mother-to-chi”
- Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Interim guidance (2020, background): “Similarly, evidence of increased severe maternal or neonatal outcomes is uncertain, and limited to infection in the third trimester, with some cases of premature rupture of membranes, fetal distress, and preterm birth reported (68, 69).”
- Prevalence, Severity and Mortality associated with COPD and Smoking in patients with COVID-19: A Rapid Systematic Review and Meta-Analysis (2020, background): “As of 25 of March 2020, the total number of confirmed case of COVID-19 stands at 459,419 with 20,818 deaths globally and the number is projected to increase [6].”
- COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives (2020, neutral): “Until now, there is no evidence for intrauterine infection by vertical transmission in women who developed COVID-19 during late pregnancy and no evidence that pregnant women are more susceptible compared with other adult patients [34,39].”