Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress: The Framingham Heart Study

By Karla M. Pou, J. Massaro, U. Hoffmann, Ramachandran S. Vasan, P. Maurovich-Horvát, Martin G. Larson, J. Keaney, James B. Meigs, I. Lipinska, Sekar Kathiresan and 4 more. Circulation, 2007

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Aging, frailty and age-related diseases (2010, background): “Most frail patients experience fatigue, disturbances of balance, decreased endurance and difficulties in adapting to changing circumstances ( Pel-Littel et al. 2009; De Lepeleire et al. 2009).”
Subcutaneous and visceral adipose tissue: structural and functional differences (2010, methodology): “Compared with SCAT, VAT was more highly associated with monocyte chemoattract protein-1 (35).”
Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study (2009, positive): “Although both subcutaneous and visceral fat depots are metabolically active (22), VAT is considered the more pathogenic compartment and is more often associated with secretion of adipokines, mediators of hemostasis and fibrinolysis, and growth factors (16).”
Adipose tissue dysfunction in obesity. (2009, background): “In the Framingham Heart Study it was shown that both visceral and subcutaneous fat mass signifi cantly correlates with markers of oxidative stress ( Pou et al., 2007 ).”
Molecular Inflammation: Underpinnings of Aging and Age-related Diseases (2008, background): “Most of pro-inflammatory cytokines are produced by adipocytes and resident macrophages in adipose tissues, causing systemic inflammation (Pou et al., 2007).”