The definition and meaning of treatment-resistant depression.

By H. Sackeim. Journal of Clinical Psychiatry, 2001

812 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d140430105ac5d4a92f77eb2a322df9402f83843

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Citations in the corpus

Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial (2013, unknown): “Patients were eligible to participate if they were 21 to 80 years of age, had a primary diagnosis of major depressive disorder as assessed with the Structured Clinical Interview for DSM-IV— Patient Edition (16), and had an inadequate response to at least three therapeutic trials of an antidepressant”
Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression (2009, methodology): “Treatment-resistance was defined as two or more failed, adequate antidepressant trials in the current episode, as determined by the Antidepressant Treatment History Form (14).”
Treatment-resistant depression: therapeutic trends, challenges, and future directions (2012, unknown): “For this purpose, it is particularly important to determine the adequacy and outcome of prior treatment trials by using the Antidepressant Treatment History Form that helps to exclude “pseudoresistance” cases.(8) Complete remission is achieved in 70%–90% of patients with depression, leaving 10%–30% ”
Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression. (2010, unknown): “There was no significant difference between patient expectancies before the first infusion and before the last infusion [t (8) .”
Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression (2012, unknown): “Food and Drug Administration (FDA)-approved antidepressant medications in the current episode according to the Antidepressant Treatment History Form (ATHF) (17).”
The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future (2017, background): “If it is to be TRD, however, then patient recruitment can be based on pre-existing criteria (Sackeim, 2001) and patients meeting them will not be rare and should not be excessively treatment resistant.”